Scientists at the University of Colorado, Denver decided to examine the effects of dietary silibinin on the growth, progression and angiogenesis of lung tumors in mice, noting that silibinin “inhibits the growth of tumors in several rodent models.”
Researchers injected mice with urethane to induce lung cancer. The rodents then received diets containing various doses of pure silibinin for 18 or 27 weeks. The researchers have been studying both silibinin and silymarin, another component of milk thistle, for over a decade in conjunction with their efficacy against various forms of cancer.
Mice receiving silibinin had “statistically significantly lower lung tumor multiplicities” than those fed a control diet. In the case of mice receiving a one percent (wt/wt) dose of silibinin for 18 weeks, there were 93% fewer large tumors compared to those in the control group.
Journal of the National Cancer Institute 98(12):846-855, 2006
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